Journal article

Association between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study

Sultana Monira Hussain, Yuanyuan Wang, Alicia K Heath, Graham G Giles, Dallas R English, Darryl W Eyles, Elizabeth J Williamson, Stephen E Graves, Anita E Wluka, Flavia M Cicuttini

BMC MUSCULOSKELETAL DISORDERS | BMC | Published : 2021

Abstract

BACKGROUND: To examine the association between circulating 25(OH)D concentrations and incidence of total hip replacement for osteoarthritis in a prospective cohort study. METHODS: This study examined a random sample of 2651 participants in the Melbourne Collaborative Cohort Study who had 25(OH)D concentrations measured from dried blood spots collected in 1990-1994. Participants who underwent total hip replacement for osteoarthritis between January 2001 and December 2018 were identified by linking the cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. Cox proportional hazard regression was used to estimate hazard ratios (HR) and 95% confidence interv..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Early Career Fellowship


Awarded by NHMRC Translating Research into Practice Fellowship


Funding Acknowledgements

The recruitment of the Melbourne Collaborative Cohort Study was supported by funding from VicHealth and Cancer Council Victoria. This study was further supported by Australian National Health and Medical Research Council (NHMRC) grants 209057, 251553, and 504711, and by infrastructure provided by Cancer Council Victoria. The vitamin D study was supported by the Australian National Health and Medical Research Council (NHMRC) grant 623208. SMH is the recipient of NHMRC Early Career Fellowship (#1142198). YW is the recipient of NHMRC Translating Research into Practice Fellowship (APP1168185). AEW is the recipient of the Royal Australian College of Physician Fellows Career Development Fellowship. The funding sources had no role in the design, conduct, or reporting of the study or the decision to submit the manuscript for publication.