Journal article

The Balance between Differentiation and Terminal Differentiation Maintains Oral Epithelial Homeostasis

Yuchen Bai, Jarryd Boath, Gabrielle R White, Uluvitike GIU Kariyawasam, Camile S Farah, Charbel Darido

CANCERS | MDPI | Published : 2021

Abstract

The oral epithelium is one of the fastest repairing and continuously renewing tissues. Stem cell activation within the basal layer of the oral epithelium fuels the rapid proliferation of multipotent progenitors. Stem cells first undergo asymmetric cell division that requires tightly controlled and orchestrated differentiation networks to maintain the pool of stem cells while producing progenitors fated for differentiation. Rapidly expanding progenitors subsequently commit to advanced differentiation programs towards terminal differentiation, a process that regulates the structural integrity and homeostasis of the oral epithelium. Therefore, the balance between differentiation and terminal di..

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Grants

Awarded by Victorian Cancer Agency mid-career Fellowship


Awarded by Garnett Passe and Rodney William Memorial Foundation


Funding Acknowledgements

This research received no external funding. Authors were funded by a Victorian Cancer Agency mid-career Fellowship (MCRF16017) to C.D., a research scholarship from the Garnett Passe and Rodney William Memorial Foundation to J.B., and a grant from the 2021 Medical Research Future Fund (MRFF 2008888) to C.S.F. and C.D.