Journal article

Neural mediators of subjective and autonomic responding during threat learning and regulation

Hannah S Savage, Christopher G Davey, Tor D Wager, Sarah N Garfinkel, Bradford A Moffat, Rebecca K Glarin, Ben J Harrison



Threat learning elicits robust changes across multiple affective domains, including changes in autonomic indices and subjective reports of fear and anxiety. It has been argued that the underlying causes of such changes may be dissociable at a neural level, but there is currently limited evidence to support this notion. To address this, we examined the neural mediators of trial-by-trial skin conductance responses (SCR), and subjective reports of anxious arousal and valence in participants (n = 27; 17 females) performing a threat reversal task during ultra-high field functional magnetic resonance imaging. This allowed us to identify brain mediators during initial threat learning and subsequent..

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Awarded by National Health and Medical Re-search Council of Australia (NHMRC)

Awarded by NHMRC Ca-reer Development Fellowship

Awarded by NIH

Funding Acknowledgements

This study was supported by a National Health and Medical Re-search Council of Australia (NHMRC) Project Grant (1161897) to BJH. HSS was supported by an Australian Government Research Training Program (RTP) Scholarship. BJH was supported by a NHMRC Ca-reer Development Fellowship (1124472) . TDW was supported by NIH R01MH116026 and R01MH076136. The authors thank Cristian Stella and Lisa Incerti for their contributions to data collection, and the par-ticipants for their involvement in the study. We acknowledge the facili-ties, and the scientific and technical assistance of the Australian National Imaging Facility, a National Collaborative Research Infrastructure Strat-egy (NCRIS) capability, at the Melbourne Brain Centre Imaging Unit (MBCIU) , The University of Melbourne. The multiband fMRI sequence was generously supported by a research collaboration agreement with CMRR, University of Minnesota and the MP2RAGE works in progress se-quence was provided by Siemens Healthineers (Germany) as advanced works in progress package.