Clinical and EEG factors associated with antiseizure medication resistance in idiopathic generalized epilepsy

BK Kamitaki; M Janmohamed; P Kandula; C Elder; R Mani; S Wong; P Perucca; T O’Brien; H Lin; GA Heiman; H Choi

Journal article

Clinical and EEG factors associated with antiseizure medication resistance in idiopathic generalized epilepsy

BK Kamitaki, M Janmohamed, P Kandula, C Elder, R Mani, S Wong, P Perucca, T O’Brien, H Lin, GA Heiman, H Choi

Epilepsia | WILEY | Published : 2022

DOI: 10.1111/epi.17104

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Abstract

Objective: We sought to determine which combination of clinical and electroencephalography (EEG) characteristics differentiate between an antiseizure medication (ASM)–resistant vs ASM-responsive outcome for patients with idiopathic generalized epilepsy (IGE). Methods: This was a case-control study of ASM-resistant cases and ASM-responsive controls with IGE treated at five epilepsy centers in the United States and Australia between 2002 and 2018. We recorded clinical characteristics and findings from the first available EEG study for each patient. We then compared characteristics of cases vs controls using multivariable logistic regression to develop a predictive model of ASM-resistant IGE. R..

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University of Melbourne Researchers

Piero Perucca Author

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Awarded by Neos Therapeutics

Funding Acknowledgements

Dr. Janmohamed is funded by an RTP stipend scholarship from Monash University. Dr. Perucca is supported by the National Health and Medical Research Council (APP1163708), the Epilepsy Foundation, the University of Melbourne, Monash University, Brain Australia, and the Weary Dunlop Research Foundation. Dr. O'Brien acknowledges funding from NHMRC Program APP1091593 and Investigator APP1176426 Grants.