Journal article

Molecular and pathology features of colorectal tumors and patient outcomes are associated with Fusobacterium nucleatum and its subspecies animalis.

Ivan Borozan, Syed H Zaidi, Tabitha A Harrison, Amanda I Phipps, Jiayin Zheng, Stephen Lee, Quang M Trinh, Robert S Steinfelder, Jeremy Adams, Barbara L Banbury, Sonja I Berndt, Stefanie Brezina, Daniel D Buchanan, Susan Bullman, Yin Cao, Alton B Farris, Jane C Figueiredo, Marios Giannakis, Lawrence E Heisler, John L Hopper Show all

Cancer Epidemiol Biomarkers Prev | Published : 2021

Abstract

BACKGROUND: Fusobacterium nucleatum activates oncogenic signaling pathways and induces inflammation to promote colorectal carcinogenesis. METHODS: We characterized F nucleatum and its subspecies in colorectal tumors and examined associations with tumor characteristics and colorectal cancer (CRC) specific survival. We conducted deep sequencing of nusA, nusG, and bacterial 16s rRNA genes in tumors from 1,994 CRC patients and assessed associations between F nucleatum presence and clinical characteristics, CRC-specific mortality, and somatic mutations. RESULTS: F nucleatum, which was present in 10.3% of tumors, was detected in a higher proportion of right-sided and advanced-stage tumors-particul..

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University of Melbourne Researchers