Tear antibodies to SARS-CoV-2: implications for transmission

KJ Selva; SK Davis; ER Haycroft; WS Lee; E Lopez; A Reynaldi; MP Davenport; HE Kent; JA Juno; AW Chung; SJ Kent

Journal article

Tear antibodies to SARS-CoV-2: implications for transmission

KJ Selva, SK Davis, ER Haycroft, WS Lee, E Lopez, A Reynaldi, MP Davenport, HE Kent, JA Juno, AW Chung, SJ Kent

Clinical and Translational Immunology | WILEY | Published : 2021

DOI: 10.1002/cti2.1354

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Abstract

Objectives: SARS-CoV-2 can be transmitted by aerosols, and the ocular surface may be an important route of transmission. Little is known about protective antibody responses to SARS-CoV-2 in tears after infection or vaccination. We analysed the SARS-CoV-2-specific IgG and IgA responses in human tears after either COVID-19 infection or vaccination. Methods: We measured the antibody responses in 16 subjects with COVID-19 infection for an average of 7 months before, and 15 subjects before and 2 weeks post-Comirnaty (Pfizer-BioNtech) vaccination. Plasma, saliva and basal tears were collected. Eleven pre-pandemic individuals were included as healthy controls. Results: IgG antibodies to spike and n..

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University of Melbourne Researchers

Kevin John Selva Author

Wen Shi Lee Author

Jennifer Juno Author

Amy Chung Author

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Funding Acknowledgements

We thank all the participants of the study and Adam Wheatley, Dale Godfrey, Nicholas Gherardin and Samuel Redman for providing key reagents. This work was supported by the Victorian government, the Medical Research Future Fund (MRFF) to JAJ, AWC, SJK and Emergent Ventures Fast Grant to AWC. MPD, JAJ, AWC and SJK are supported by NHMRC Fellowships.