Serological and cellular inflammatory signatures in end-stage kidney disease and latent tuberculosis

MR McLean; KM Wragg; E Lopez; SA Kiazyk; TB Ball; J Bueti; SJ Kent; JA Juno; AW Chung

Journal article

Serological and cellular inflammatory signatures in end-stage kidney disease and latent tuberculosis

MR McLean, KM Wragg, E Lopez, SA Kiazyk, TB Ball, J Bueti, SJ Kent, JA Juno, AW Chung

Clinical and Translational Immunology | Published : 2021

DOI: 10.1002/cti2.1355

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Abstract

Objectives: Tuberculosis comorbidity with chronic diseases including diabetes, HIV and chronic kidney disease is of rising concern. In particular, latent tuberculosis infection (LTBI) comorbidity with end-stage kidney disease (ESKD) is associated with up to 52.5-fold increased risk of TB reactivation to active tuberculosis infection (ATBI). The immunological mechanisms driving this significant rise in TB reactivation are poorly understood. To contribute to this understanding, we performed a comprehensive assessment of soluble and cellular immune features amongst a unique cohort of patients comorbid with ESKD and LTBI. Methods: We assessed the plasma and cellular immune profiles from patients..

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University of Melbourne Researchers

Milla McLean Author Microbiology and Immunology

Kathleen Wragg Author

Stephen Kent Author

Jennifer Juno Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by an NHMRC Project grant (GNT1163790 to TBB, JAJ and AWC). SJK, JAJ and AWC are supported by NHMRC fellowships (GNT1136322, GNT2009308 and GNT1140509). We thank Dr Timon Damelang for assisting with the upkeep and training of MM on the multiplex machines and running PCA scripts.