Journal article

Type 1 conventional dendritic cells: ontogeny, function, and emerging roles in cancer immunotherapy

Shengbo Zhang, Michael Chopin, Stephen L Nutt

TRENDS IN IMMUNOLOGY | ELSEVIER SCI LTD | Published : 2021

Abstract

Dendritic cells (DCs) are key immune sentinels that orchestrate protective immune responses against pathogens or cancers. DCs have evolved into multiple phenotypically, anatomically, and functionally distinct cell types. One of these DC types, Type 1 conventional DCs (cDC1s), are uniquely equipped to promote cytotoxic CD8+ T cell differentiation and, therefore, represent a promising target for harnessing antitumor immunity. Indeed, recent studies have highlighted the importance of cDC1s in tumor immunotherapy using immune checkpoint inhibitors. Here, we review the progress in defining the key developmental and functional attributes of cDC1s and the approaches to optimizing the potency of cDC..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

We thank Andrew Lew for critical reading of this manuscript. This work was supported by the National Health and Medical Research Council of Australia grants; 1196235 (M.C.) 1155342 (S.L.N.) , and the Melbourne research scholarship (S.Z.) . This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS.