Effects of a physical activity intervention on brain atrophy in older adults at risk of dementia: a randomized controlled trial
Benjamin Sinclair, Chris Steward, Vijay Venkatraman, Rowa Aljondi, Kay L Cox, Kathryn A Ellis, David Ames, Colin L Masters, Pramit M Phal, Matthew J Sharman, Elizabeth Cyarto, Michelle MY Lai, Cassandra Szoeke, Nicola T Lautenschlager, Patricia M Desmond
BRAIN IMAGING AND BEHAVIOR | SPRINGER | Published : 2021
Lack of physical activity is a risk factor for dementia, however, the utility of interventional physical activity programs as a protective measure against brain atrophy and cognitive decline is uncertain. Here we present the effect of a randomized controlled trial of a 24-month physical activity intervention on global and regional brain atrophy as characterized by longitudinal voxel-based morphometry with T1-weighted MRI images. The study sample consisted of 98 participants at risk of dementia, with mild cognitive impairment or subjective memory complaints, and having at least one vascular risk factor for dementia, randomized into an exercise group and a control group. Between 0 and 24 month..View full abstract
Awarded by Australian National Health and Medical Research Council
Awarded by Medical Research Council Centre of Excellence grant
This work is supported by a project grant from the Australian National Health and Medical Research Council awarded to NTL, PMD, KC, DA, CS, KAE, PMP, MJS, and CM (ID: 1005492) and a Medical Research Council Centre of Excellence grant (ID: 1100579) (awarded to NTL, KAE, KC).