Journal article
Unleashing TNF cytotoxicity to enhance cancer immunotherapy
Andrew J Freeman, Conor J Kearney, John Silke, Jane Oliaro
TRENDS IN IMMUNOLOGY | ELSEVIER SCI LTD | Published : 2021
Abstract
Tumor necrosis factor (TNF) is a proinflammatory cytokine that is produced and secreted by cytotoxic lymphocytes upon tumor target recognition. Depending on the context, TNF can mediate either pro-survival or pro-death signals. The potential cytotoxicity of T cell-produced TNF, particularly in the context of T cell-directed immunotherapies, has been largely overlooked. However, a spate of recent studies investigating tumor immune evasion through the application of CRISPR-based gene-editing screens have highlighted TNF-mediated killing as an important component of the mammalian T cell antitumor repertoire. In the context of the current understanding of the role of TNF in antitumor immunity, w..
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Grants
Awarded by NHMRC
Awarded by National Breast Cancer Foundation
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
A.J.F. was supported by scholarships from Australian Commonwealth Government, Steer North Australia, and the Peter MacCallum Cancer Foundation. C.J.K. was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship. J.S. was supported by a NHMRC Research Fellowship (1195038) . J.O. was supported by NHMRC (1139626) and National Breast Cancer Foundation (IIRS-18-151) project grants.