Journal article

Evidence of neuroinflammation and blood–brain barrier disruption in women with preeclampsia and eclampsia

L Bergman, R Hastie, H Zetterberg, K Blennow, S Schell, E Langenegger, A Moodley, S Walker, S Tong, C Cluver

Cells | Published : 2021

Abstract

Cerebral complications in preeclampsia are leading causes of maternal mortality. Animal models suggest that an injured blood–brain barrier and neuroinflammation may be important but there is paucity of data from human studies. Therefore, we aimed to evaluate this in women with preeclampsia and eclampsia. We included women recruited to the South African Preeclampsia Obstetric Adverse Events (PROVE) biobank. Blood and cerebrospinal fluid (CSF) were collected around delivery. CSF was analyzed for neuroinflammatory markers interleukin 1β, interleukin 6, interleukin-8 and tumor necrosis factor alpha (TNF-alpha). The CSF to plasma albumin ratio was measured to assess blood–brain barrier function. ..

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