Journal article
Evidence of neuroinflammation and blood–brain barrier disruption in women with preeclampsia and eclampsia
L Bergman, R Hastie, H Zetterberg, K Blennow, S Schell, E Langenegger, A Moodley, S Walker, S Tong, C Cluver
Cells | MDPI | Published : 2021
Open access
Abstract
Cerebral complications in preeclampsia are leading causes of maternal mortality. Animal models suggest that an injured blood–brain barrier and neuroinflammation may be important but there is paucity of data from human studies. Therefore, we aimed to evaluate this in women with preeclampsia and eclampsia. We included women recruited to the South African Preeclampsia Obstetric Adverse Events (PROVE) biobank. Blood and cerebrospinal fluid (CSF) were collected around delivery. CSF was analyzed for neuroinflammatory markers interleukin 1β, interleukin 6, interleukin-8 and tumor necrosis factor alpha (TNF-alpha). The CSF to plasma albumin ratio was measured to assess blood–brain barrier function. ..
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Awarded by Alzheimer's Association
Funding Acknowledgements
The study was supported by the Swedish Medical Society, Marta Lundqvist Foundation, Swedish Foundation for International Cooperation in Research and Higher Education (STINT), Jane and Dan Olssons Foundation, Mercy Perinatal, the Swedish Research Council (VR), Center for Clinical Research Dalarna and the Preeclampsia Foundation. L.B. is supported by the Swedish Society for Medical Research (SSMF). C.C. receives salary support from the Mercy Health Foundation. R.H. and S.T. receive salary support from the National Health and Medical Research Council of Australia (NHMRC). H.Z. is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2018-02532), the European Research Council (#681712), Swedish State Support for Clinical Research (#ALFGBG-720931), the Alzheimer Drug Discovery Foundation (ADDF), USA (#201809-2016862), the AD Strategic Fund and the Alzheimer's Association (#ADSF-21-831376-C, #ADSF-21-831381-C and #ADSF-21-831377-C), the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen for Gamla Tjanarinnor, Hjarnfonden, Sweden (#FO2019-0228), the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 860197 (MIRIADE) and the UK Dementia Research Institute at UCL.