Journal article
Restrictive versus liberal transfusion in patients with diabetes undergoing cardiac surgery: An open-label, randomized, blinded outcome evaluation trial
N Mistry, N Shehata, P Carmona, D Bolliger, R Hu, FM Carrier, CS Alphonsus, EE Tseng, AG Royse, C Royse, D Filipescu, C Mehta, T Saha, JC Villar, AJ Gregory, DN Wijeysundera, KE Thorpe, P Jüni, GMT Hare, DT Ko Show all
Diabetes Obesity and Metabolism | Published : 2022
DOI: 10.1111/dom.14591
Abstract
Aim: To characterize the association between diabetes and transfusion and clinical outcomes in cardiac surgery, and to evaluate whether restrictive transfusion thresholds are harmful in these patients. Materials and Methods: The multinational, open-label, randomized controlled TRICS-III trial assessed a restrictive transfusion strategy (haemoglobin [Hb] transfusion threshold <75 g/L) compared with a liberal strategy (Hb <95 g/L for operating room or intensive care unit; or <85 g/L for ward) in patients undergoing cardiac surgery on cardiopulmonary bypass with a moderate-to-high risk of death (EuroSCORE ≥6). Diabetes status was collected preoperatively. The primary composite outcome was all-c..
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Awarded by National Institutes of Health
Funding Acknowledgements
The authors thank the TRICS investigators for their contributions to the study. A list of participating TRICS investigators is provided in the supporting information (Appendix). The TRICS-III trial was funded by grants from the Canadian Institutes of Health Research (232416 and 301852), the Kenneth J. Fyke Award from the Canadian Blood Services-Health Canada, the National Health and Medical Research Council of Australia (1085942), the Health Research Council of New Zealand (16/353), and the National Institutes of Health (R01HL119857). The funders had no role in the design, conduct, analysis, or interpretation of data.