Journal article

Biology and Treatment Advances in Cutaneous Squamous Cell Carcinoma

Alesha A Thai, Annette M Lim, Benjamin J Solomon, Danny Rischin

CANCERS | MDPI | Published : 2021

Abstract

Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer diagnosed worldwide. CSCC is generally localized and managed with local therapies such as excision and/or radiotherapy. For patients with unresectable or metastatic disease, recent improvements in our understanding of the underlying biology have led to significant advancements in treatment approaches-including the use of immune checkpoint inhibition (ICI)-which have resulted in substantial gains in response and survival compared to traditional cytotoxic approaches. However, there is a lack of understanding of the biology underpinning CSCC in immunocompromised patients, in whom the risk of developing CSCC is hundre..

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