Journal article
Neuroendocrine cells in prostate cancer correlate with poor outcomes: a systematic review and meta-analysis
Ashwini Kannan, David Clouston, Mark Frydenberg, Dragan Ilic, Md Nazmul Karim, Sue M Evans, Roxanne Toivanen, Gail P Risbridger, Renea A Taylor
BJU INTERNATIONAL | WILEY | Published : 2022
DOI: 10.1111/bju.15647
Abstract
Objectives: To perform a systematic review and meta-analysis of the literature to understand the variation in the reporting of neuroendocrine staining and determine the influence of reporting neuroendocrine staining at diagnosis on patient outcomes. Methods: Medical databases were searched to identify studies in which adenocarcinoma specimens were stained with any of the following four neuroendocrine markers: chromogranin A (CgA), neuron-specific enolase (NSE), synaptophysin and CD56. The prevalence of neuroendocrine staining and correlation of the prevalence of neuroendocrine staining to patient outcomes were analysed using a random-effects model. All statistical tests were two-sided. Resul..
View full abstractGrants
Awarded by National Health and Medical Research Council, Australia
Awarded by Department of Health and Human Services acting through the Victorian Cancer Agency
Awarded by Prostate Cancer Foundation of Australia (Young Investigator Award)
Awarded by Peter MacCallum Cancer Foundation (New Investigator Grant)
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This work was supported by: the National Health and Medical Research Council, Australia (fellowships 1102752 to G.P.R., 1090204 to R.T., project grant 1185616); the Department of Health and Human Services acting through the Victorian Cancer Agency (fellowships, MCRF15023 to R.A.T., MCRF18012 to R.T., CAPTIV Program); the Prostate Cancer Foundation of Australia (Young Investigator Award YI 0417 to R.T.); the Peter MacCallum Cancer Foundation (New Investigator Grant 1752 to R.T.); the EJ Whitten Foundation; the Peter and Lyndy White Foundation; and TissuPath Pathology. The funders had no role in the design of the study, the collection, analysis and interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication.