Regional Targeting of Bladder and Urethra Afferents in the Lumbosacral Spinal Cord of Male and Female Rats: A Multiscale Analysis
JP Fuller-Jackson, PB Osborne, JR Keast
ENEURO | SOC NEUROSCIENCE | Published : 2021
Sensorimotor circuits of the lumbosacral spinal cord are required for lower urinary tract (LUT) regulation as well as being engaged in pelvic pain states. To date, no molecular markers have been identified to enable specific visualization of LUT afferents, which are embedded within spinal cord segments that also subserve somatic functions. Moreover, previous studies have not fully investigated the patterning within or across spinal segments, compared afferent innervation of the bladder and urethra, or explored possible structural sex differences in these pathways. We have addressed these questions in adult Sprague Dawley rats, using intramural microinjection of the tract tracer, B subunit of..View full abstract
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Awarded by Office of the Director, Stimulating Peripheral Activity to Relieve Conditions (SPARC) Program, National Institutes of Health
This work was supported by the Office of the Director, Stimulating Peripheral Activity to Relieve Conditions (SPARC) Program, National Institutes of Health under Award Number OT2OD023872 (to J.R.K. and P.B.O.).