A Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes

Barbora Paldus; Dale Morrison; Dessi P Zaharieva; Melissa H Lee; Hannah Jones; Varuni Obeyesekere; Jean Lu; Sara Vogrin; Andre La Gerche; Sybil A McAuley; Richard J MacIsaac; Alicia J Jenkins; Glenn M Ward; Peter Colman; Carmel EM Smart; Rowen Seckold; Bruce R King; Michael C Riddell; David N O'Neal

Journal article

A Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes

Barbora Paldus, Dale Morrison, Dessi P Zaharieva, Melissa H Lee, Hannah Jones, Varuni Obeyesekere, Jean Lu, Sara Vogrin, Andre La Gerche, Sybil A McAuley, Richard J MacIsaac, Alicia J Jenkins, Glenn M Ward, Peter Colman, Carmel EM Smart, Rowen Seckold, Bruce R King, Michael C Riddell, David N O'Neal

DIABETES CARE | AMER DIABETES ASSOC | Published : 2022

DOI: 10.2337/dc21-1593

Abstract

OBJECTIVE: To compare glucose control with hybrid closed-loop (HCL) when challenged by high intensity exercise (HIE), moderate intensity exercise (MIE), and resistance exercise (RE) while profiling counterregulatory hormones, lactate, ketones, and kinetic data in adults with type 1 diabetes. RESEARCH DESIGN AND METHODS: This study was an open-label multisite randomized crossover trial. Adults with type 1 diabetes undertook 40 min of HIE, MIE, and RE in random order while using HCL (Medtronic MiniMed 670G) with a temporary target set 2 h prior to and during exercise and 15 g carbohydrates if pre-exercise glucose was <126 mg/dL to prevent hypoglycemia. Primary outcome was median (interquartile..

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University of Melbourne Researchers

Dale Morrison Author

Melissa Lee Author

Sara Vogrin Author

Andre La Gerche Author

Grants

Awarded by JDRF International

Awarded by JDRF Early-Career Patient-Oriented Diabetes Research Award

Funding Acknowledgements

This trial was funded by the Leona M. and Harry B. Helmsley Charitable Trust and JDRF International (3-SRA-2018-532-M-B). In-kind support was provided by Medtronic (HCL systems and technical expertise with device issues). B.P. is supported by a University of Melbourne scholarship and research support from JDRF. D.P.Z. is supported by a Leona M. and Harry B. Helmsley Charitable Trust grant and International Society for Pediatric and Adolescent DiabetesJDRF research fellowship. M.H.L. is supported by a National Health and Medical Research Council (NHMRC) postgraduate scholarship, cofunded by Diabetes Australia. S.A.M. is supported by a JDRF Early-Career Patient-Oriented Diabetes Research Award (5-ECR-2017-371-A-N). A.J.J. is supported by an NHMRC Fellowship and is a Sydney Medical School Foundation Fellow and received research support from the NHMRC of Australia, JDRF Australia, and JDRF International. R.J.M. received research grants from the Rebecca L. Cooper Medical Research Foundation, St Vincent's Foundation, JDRF, Diabetes Australia Research Trust/Program, and the NHMRC of Australia.