Journal article
A polygenic risk score predicts incident prostate cancer risk in older men but does not select for clinically significant disease
A Bakshi, M Riaz, SG Orchard, PR Carr, AD Joshi, Y Cao, R Rebello, T Nguyen-Dumont, MC Southey, JL Millar, L Gately, P Gibbs, LG Ford, HL Parnes, AT Chan, JJ McNeil, P Lacaze
Cancers | MDPI | Published : 2021
Abstract
Despite the high prevalence of prostate cancer in older men, the predictive value of a polygenic risk score (PRS) remains uncertain in men aged ≥70 years. We used a 6.6 million-variant PRS to predict the risk of incident prostate cancer in a prospective study of 5701 men of European descent aged ≥70 years (mean age 75 years) enrolled in the ASPirin in Reducing Events in the Elderly (ASPREE) clinical trial. The study endpoint was prostate cancer, including metastatic or non-metastatic disease, confirmed by an expert panel. After excluding participants with a history of prostate cancer at enrolment, we used a multivariable Cox proportional hazards model to assess the association between the PR..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by an ASPREE Flagship cluster grant (including the Commonwealth Scientific and Industrial Research Organisation, Monash University, Menzies Research Institute, Australian National University, University of Melbourne); and grants (U01AG029824 and U19AG062682) from the National Institute on Aging and the National Cancer Institute at the National Institutes of Health, by grants (334047 and 1127060) from the National Health and Medical Research Council of Australia, and by Monash University and the Victorian Cancer Agency. YC is supported by K07CA218377. ATC is supported by an NCI Outstanding Investigator Award (R35 CA253185). JM is supported by a NHMRC Leadership Fellowship Investigator Grant (ID 1173690). PL is supported by a National Heart Foundation Future Leader Fellowship (ID 102604).