Journal article

Effective Management of Severe Asthma with Biologic Medications in Adult Patients: A Literature Review and International Expert Opinion.

Roland Buhl, Elisabeth Bel, Arnaud Bourdin, Ignacio Dávila, Jo A Douglass, J Mark FitzGerald, David J Jackson, Njira Lugogo, Andrea Matucci, Ian D Pavord, Michael E Wechsler, Monica Kraft

J Allergy Clin Immunol Pract | Published : 2021

Abstract

Severe asthma often remains uncontrolled despite effective treatments and evidence-based guidelines. A group of global experts in asthma and biologic medications from nine countries considered the most relevant clinical variables to manage severe asthma in adult patients and guide treatment choice. The resulting recommendations address the investigation of biomarker levels (blood eosinophil count along with fractional concentration of exhaled nitric oxide [FeNO]), clinical features (oral corticosteroid [OCS] dependency, specific comorbid disease entities associated with severe type 2 asthma), and safety considerations. Current evidence suggests that biomarkers, including both blood or sputum..

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