Journal article
A case report describing the immune response of an infant with congenital heart disease and severe COVID-19
D Wurzel, MR Neeland, J Anderson, YN Abo, LAH Do, CM Donato, JE Bines, ZQ Toh, RA Higgins, S Jalali, T Cole, K Subbarao, A McMinn, K Dohle, GM Haeusler, S McNab, A Alafaci, I Overmars, V Clifford, LY Lee Show all
Communications Medicine | Published : 2021
Abstract
Background: Children with SARS-CoV-2 infection generally present with milder symptoms or are asymptomatic in comparison with adults, however severe disease occurs in a subset of children. To date, the immune correlates of severe COVID-19 in young children have been poorly characterised. Methods: We report the kinetics of immune responses in relation to clinical and virological features in an infant with acute severe COVID-19 using high-dimensional flow cytometry and multiplex cytokine analysis. Results: Systemic cellular and cytokine profiling show an initial increase in neutrophils and monocytes with depletion of lymphoid cell populations (particularly CD8 + T and NK cells) and elevated inf..
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Funding Acknowledgements
First, we wish to acknowledge this child's family for their generosity and willingness to contribute to research at a time of great stress. We also acknowledge the Clinical Laboratory team at The Royal Children's Hospital, Melbourne for their support. This study was funded by Murdoch Children's Research Institute COVID-19 research program; Centres of Excellence in Influenza Research and Surveillance-Cross-Centre Southern Hemisphere Project, National Institute of Health (NIH); The Influenza Complications Alert Network Surveillance System (FluCAN); Paediatric Active Enhanced Disease Surveillance (PAEDS) and Sentinel Travellers and Research Preparedness Platform for Emerging Infectious Disease (SETREP-ID)-Australian Partnership for Preparedness Research on Infectious Disease Emergencies. Funding was also provided through the Victoria Government's Operational Infrastructure Support Programme. P.V.L. is supported by Australian National Health and Medical Research Council (NHMRC) Career Development Fellowship. DGP is supported by a CSL Centenary Fellowship.