Journal article
Estimating nocturnal stroke onset times by magnetic resonance imaging in the WAKE-UP trial
B Cheng, H Pinnschmidt, A Königsberg, E Schlemm, F Boutitie, M Ebinger, M Endres, JB Fiebach, J Fiehler, I Galinovic, R Lemmens, KW Muir, S Pedraza, J Puig, CZ Simonsen, V Thijs, A Wouters, C Gerloff, G Thomalla
International Journal of Stroke | Published : 2022
Abstract
Background: Fluid-attenuated inversion recovery (FLAIR) sequences have gained a role to guide treatment of patients with unknown time of stroke symptom onset. Evolution of signal intensities in FLAIR is associated with time since stroke onset with continuous linear increases. Aims: Estimating symptom onset during night-sleep in patients from the WAKE-UP trial based on relative signal intensities FLAIR (FLAIR-rSI) from acute stroke lesions an independent dataset (PRE-FLAIR study). Methods: FLAIR-rSI was quantified in stroke lesions in PRE-FLAIR and WAKE-UP. The PRE-FLAIR study was a multicenter observational trial establishing FLAIR as a surrogate parameter for time since stroke onset. WAKE-U..
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Awarded by Pfizer
Funding Acknowledgements
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: WAKE-UP received funding from the European Union Seventh Framework Program [FP7/2007-2013] under grant agreement no 278276 (WAKE-UP).