Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin
David G Le Couteur, Samantha M Solon-Biet, Benjamin L Parker, Tamara Pulpitel, Amanda E Brandon, Nicholas J Hunt, Jibran A Wali, Rahul Gokarn, Alistair M Senior, Gregory J Cooney, David Raubenheimer, Victoria C Cogger, David E James, Stephen J Simpson
CELL METABOLISM | CELL PRESS | Published : 2021
Nutrient sensing pathways influence metabolic health and aging, offering the possibility that diet might be used therapeutically, alone or with drugs targeting these pathways. We used the Geometric Framework for Nutrition to study interactive and comparative effects of diet and drugs on the hepatic proteome in mice across 40 dietary treatments differing in macronutrient ratios, energy density, and drug treatment (metformin, rapamycin, resveratrol). There was a strong negative correlation between dietary energy and the spliceosome and a strong positive correlation between dietary protein and mitochondria, generating oxidative stress at high protein intake. Metformin, rapamycin, and resveratro..View full abstract
Awarded by National Health and Medical Research Coun-cil of Australia (NHMRC)
We acknowledge the support by National Health and Medical Research Coun-cil of Australia (NHMRC) project grant 1084267, and program grant 1149976.