Journal article
Scoping Review of Antimalarial Drug Candidates in Phase I and II Drug Development
AN Abd-Rahman, S Zaloumis, JS McCarthy, JA Simpson, RJ Commons
Antimicrobial Agents and Chemotherapy | Published : 2022
DOI: 10.1128/aac.01659-21
Abstract
The emergence and spread of parasite resistance to currently available antimalarials has highlighted the importance of developing novel antimalarials. This scoping review provides an overview of antimalarial drug candidates undergoing phase I and II studies between 1 January 2016 and 28 April 2021. PubMed, Web of Science, Embase, clinical trial registries, and reference lists were searched for relevant studies. Information regarding antimalarial compound details, clinical trial characteristics, study population, and drug pharmacokinetics and pharmacodynamics (PK-PD) were extracted. A total of 50 studies were included, of which 24 had published their results and 26 were unpublished. New antim..
View full abstractRelated Projects (2)
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work is supported in part by the Australian Centre for Research Excellence in Malaria Elimination, funded by the Australian National Health and Medical Research Council of Australia (NHMRC; 1134989). J.A.S. is funded by an Australian NHMRC Leadership Investigator Grant (1196068). J.S.M. is funded by an NHMRC Program Grant (1132975) and Practitioner Fellowship (1041802). R.J.C. is supported by an Australian NHMRC Emerging Leader Investigator Grant (1194702). The review was done completely independent from any funding bodies.