Conference Proceedings
LOW AND INTERMEDIATE GRADE GLIOMA UMBRELLA STUDY OF MOLECULAR GUIDED THERAPIES (LUMOS) STUDY
Benjamin Kong, Hao-Wen Sim, Benhur Amanuel, Bryan Day, Michael Buckland, Roel Verhaak, Sonia Yip, Terrance Johns, Zarnie Lwin, Mark Rosenthal, Anna K Nowak, Elizabeth H Barnes, Andrew M Scott, Jonathon Parkinson, Rosalind Jeffree, Richard De Abreu Lourenco, Peter Lau, James Whittle, Elizabeth Hovey, Lawrence Cher Show all
NEURO-ONCOLOGY | OXFORD UNIV PRESS INC | Published : 2021
Abstract
Abstract BACKGROUND Grade 2 and 3 (G2/3) gliomas are the second largest group of brain tumors in adults. Although the prognosis for G2/3 gliomas at the time of relapse mirror those of glioblastoma, there are few trials in this space. METHODS LUMOS was a national multi-center pilot study for patients with relapsed G2/3 gliomas designed to match contemporaneous tissue obtained at the time of disease progression with subsequent targeted therapies. The objective was to establish the feasibility of a precision oncology, umbrella approach to obtain and type tissue within a useful..
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