Journal article
Antibody Targets and Properties for Complement-Fixation Against the Circumsporozoite Protein in Malaria Immunity
L Kurtovic, DR Drew, AE Dent, JW Kazura, JG Beeson
Frontiers in Immunology | Published : 2021
Abstract
The Plasmodium falciparum circumsporozoite protein (CSP) forms the basis of leading subunit malaria vaccine candidates. However, the mechanisms and specific targets of immunity are poorly defined. Recent findings suggest that antibody-mediated complement-fixation and activation play an important role in immunity. Here, we investigated the regions of CSP targeted by functional complement-fixing antibodies and the antibody properties associated with this activity. We quantified IgG, IgM, and functional complement-fixing antibody responses to different regions of CSP among Kenyan adults naturally exposed to malaria (n=102) and using a series of rabbit vaccination studies. Individuals who acquir..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
This work was funded by the National Health and Medical Research Council (NHMRC) of Australia (Program Grant 1092789, Project Grant 1141278, and Investigator Grant 1173046 to JB) and the Australian Government Research training Program Scholarship to LK, and the NIH International Centers for Excellence in Malaria Research (U19 AI129326).