Lignocaine versus opioids in coronary intervention: assessing antiplatelet activity and ticagrelor levels (LOCAL) study

H Fernando; T Duong; K Huynh; J Noonan; J Shaw; S Duffy; Z Nehme; K Smith; P Myles; P Meikle; K Peter; D Stub

Journal article

Lignocaine versus opioids in coronary intervention: assessing antiplatelet activity and ticagrelor levels (LOCAL) study

H Fernando, T Duong, K Huynh, J Noonan, J Shaw, S Duffy, Z Nehme, K Smith, P Myles, P Meikle, K Peter, D Stub

EUROPEAN HEART JOURNAL | OXFORD UNIV PRESS | Published : 2021

DOI: 10.1093/eurheartj/ehab724.2991

Abstract

Abstract Background Opioid analgesia impairs the bioavailability and antiplatelet effect of oral P2Y12 inhibitors prompting investigation of mitigation strategies including identifying alternative analgesic agents. Purpose To assess the impact of intravenous fentanyl and lignocaine on the bioavailability and antiplatelet effect of ticagrelor in patients with unstable angina and non-ST elevation myocardial infarction, as well as their procedural analgesic efficacy and safety. Methods The LOCAL trial was a pr..

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