Journal article
DNA methylation in childhood dental caries and hypomineralization
S MJ, M N, C JM, M DJ, S R, S MC, B DP, L J, K NM, H JL, S KJ, L S
Journal of Dentistry | Published : 2022
Abstract
Objectives: Epigenetic modulation of gene expression may be important in dental conditions, including dental caries and enamel hypomineralisation. The aims of this study were to assess associations between DNA methylation in cord blood leucocytes at birth, and caries experience and enamel hypomineralisation at six years of age. Method: The study sample was from a birth cohort study of twins. Dental examinations at six years identified the presence/absence of (i) ‘any caries’ (untreated and treated caries), (ii) ‘advanced caries’ (untreated, advanced caries and/or past treatment) and (iii) hypomineralised second primary molars (HSPM). Genome-wide analysis of DNA methylation was performed on c..
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Awarded by State Government of Victoria
Funding Acknowledgements
The research in this publication was supported by the National Institute of Dental and Craniofacial Research of the National Institutes of Health under Award Number R01DE019665. The Peri/Postnatal Epigenetic Twins Study (PETS) was supported by grants from the Australian National Health and Medical Research Council (NHMRC) (GTN437015 and GTN607358), the Bonnie Babes Foundation (grant number BBF20704), the Financial Markets Foundation for Children (grant number 032-2007), the Victorian Government's Operational Infrastructure Support Program, the Australian and New Zealand Society for Paediatric Dentistry Victorian Branch and The University of Melbourne Paediatric Dentistry Fund. MS is supported by a Melbourne Children's Clinician-Scientist Fellowship. KS is supported by a Centre of Research Excellence Grant in Twin Research and a NHMRC project grant (GTN1084197). DB is supported by an NHMRC Investigator Grant (GTN1175744). MCS is a NHMRC Senior Research Fellow (APP1155163). JLH is a NHMRC Senior Principal Research Fellow. SL is a Victorian Cancer Agency Early Career Research Fellow (ECRF19020).