Experimental human hookworm infection: a narrative historical review
Paul R Chapman, Paul Giacomin, Alex Loukas, James S McCarthy
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2021
In 1896, a serendipitous laboratory accident led to the understanding that hookworms propagate infection by penetrating skin, a theory that was then confirmed with the first experimental human infection, reported in 1901. Experimental human infections undertaken in the 20th century enabled understanding of the natural history of infection and the immune response. More recently, experimental hookworm infection has been performed to investigate the immunomodulatory potential of hookworm infection and for the evaluation of hookworm vaccines and chemotherapeutic interventions. Experimental human hookworm infection has been proven to be safe, with no deaths observed in over 500 participants (alth..View full abstract
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Awarded by NHMRC
AL is supported by a senior principal research fellowship from NHMRC (1117504), JSM is supported by a NHMRC Practitioner Fellowship (1135955), PG is supported by NHMRC grant (1105300). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.