Journal article
Electrically evoked and spontaneous neural activity in the subthalamic nucleus under general anesthesia
NC Sinclair, HJ McDermott, WL Lee, SS Xu, N Acevedo, A Begg, T Perera, W Thevathasan, KJ Bulluss
Journal of Neurosurgery | AMER ASSOC NEUROLOGICAL SURGEONS | Published : 2022
Abstract
OBJECTIVE Deep brain stimulation (DBS) surgery is commonly performed with the patient awake to facilitate assessments of electrode positioning. However, awake neurosurgery can be a barrier to patients receiving DBS. Electrode implantation can be performed with the patient under general anesthesia (GA) using intraoperative imaging, although such techniques are not widely available. Electrophysiological features can also aid in the identification of target neural regions and provide functional evidence of electrode placement. Here we assess the presence and positional variation under GA of spontaneous beta and high-frequency oscillation (HFO) activity, and evoked resonant neural activity (ERNA..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
James Fallon provided statistical advice. Graham Lethbridge and Sesto Cairo were the attending anesthetists who determined and applied the anesthetic regimes during surgery at St. Vincent's Private and Cabrini Hospital, respectively. This work was supported by the Colonial Foundation, St. Vincent's Hospital Research Endowment Fund, and the National Health and Medical Research Council (project grant no. 1103238, development grant no. 1177815). The Bionics Institute acknowl-edges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. N.C.S. is supported through an Australian Government Research Training Program Scholarship. W.T. is supported by Lions International and the National Health and Medical Research Council.