Journal article
DBS of Thalamic Centromedian Nucleus for Lennox–Gastaut Syndrome (ESTEL Trial)
LJ Dalic, AEL Warren, KJ Bulluss, W Thevathasan, A Roten, L Churilov, JS Archer
Annals of Neurology | Published : 2022
DOI: 10.1002/ana.26280
Abstract
Objective: Prior uncontrolled studies have reported seizure reductions following deep brain stimulation (DBS) in patients with Lennox–Gastaut syndrome (LGS), but evidence from randomized controlled studies is lacking. We aimed to formally assess the efficacy and safety of DBS to the centromedian thalamic nucleus (CM) for the treatment of LGS. Methods: We conducted a prospective, double-blind, randomized study of continuous, cycling stimulation of CM-DBS, in patients with LGS. Following pre- and post-implantation periods, half received 3 months of stimulation (blinded phase), then all received 3 months of stimulation (unblinded phase). The primary outcome was the proportion of participants wi..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors thank the participants and their families/carers for participating in this research. We thank our colleagues who referred participants for involvement in the ESTEL trial, with particular thanks to Professor Ingrid Scheffer in this regard, and for her invaluable clinical support throughout and beyond the trial. We thank Professor Samuel Berkovic for his role in safety oversight as our onsite independent clinician and continuous support for the study. Our work was supported with funding from the National Health and Medical Research Council (Project Grant #1108881). L.J.D. is supported by an Australian Government Research Training Program Scholarship. A.E.L.W. is supported by a post-doctoral fellowship from the Lennox-Gastaut syndrome Foundation and an Early Career Researcher Grant from the University of Melbourne.