Journal article
Expression of the miR-17~92a cluster of microRNAs by regulatory T cells controls blood glucose homeostasis
Y Zhang, JP Skinner, MMW Chong
Immunology and Cell Biology | Published : 2022
DOI: 10.1111/imcb.12513
Abstract
Regulatory T cells (Tregs) are a specialized immune cell type that play important roles in regulating immune responses. However, those found in adipose tissue, particularly visceral adipose tissue (VAT), have also been shown to exert metabolic regulatory functions. This study investigated the requirement of the miR-17~92a cluster of microRNAs in VAT Tregs and the impact on blood glucose. This cluster of microRNAs is one that we previously showed to be important for the fitness of Tregs found in secondary lymphoid organs. It was found that male mice with Treg-specific miR-17~92a deficiency are resistant to impaired glucose tolerance induced by a high-fat diet. However, high-fat feeding still ..
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Awarded by U.S. Department of Defense
Funding Acknowledgements
The authors thank St Vincent's Hospital Melbourne's BioResources Centre's Vicki Moshovakis and Rhiannon Walder for assistance with the glucose tolerance tests and Lucy Kloboucnik and Vincent Madafferi for expert animal husbandry. This work was funded by grants from the National Health and Medical Research Council (GNT1122384 and GNT1122395), Diabetes Australia (Y20G-CHOM) and the U.S. Department of Defense (W81XWH-19-1-0728). MMWC is a Senior Research Fellow of the National Health and Medical Research Council. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian National Health and Medical Research Council Research Institute Infrastructure Support Schemes.