The Potential of Calcium Phosphate Nanoparticles as Adjuvants and Vaccine Delivery Vehicles

Z Sun; W Li; JC Lenzo; JA Holden; MJ McCullough; AJ O’Connor; NM O’Brien-Simpson

Journal article

The Potential of Calcium Phosphate Nanoparticles as Adjuvants and Vaccine Delivery Vehicles

Z Sun, W Li, JC Lenzo, JA Holden, MJ McCullough, AJ O’Connor, NM O’Brien-Simpson

Frontiers in Materials | FRONTIERS MEDIA SA | Published : 2021

DOI: 10.3389/fmats.2021.788373

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Abstract

Vaccination is one of the most efficacious and cost-effective ways to protect people from infectious diseases and potentially cancer. The shift in vaccine design from disrupted whole pathogens to subunit antigens has brought attention on to vaccine delivery materials. For the last two decades, nanotechnology-based vaccines have attracted considerable attention as delivery vehicles and adjuvants to enhance immunogenicity, exemplified with the current COVID vaccines. The nanoparticle vaccines display unique features in protecting antigens from degradation, controlled antigen release and longer persisting immune response. Due to their size, shape and surface charge, they can be outstanding adju..

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University of Melbourne Researchers

Wenyi Li Author

James Holden Author

Michael McCullough Author

Andrea O'Connor Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

The National Health and Medical Research Council (NHMRC) of Australia and Australian Rehsearch Council (ARC) are thanked for financial support over many years for the peptide chemistry and chemical biology studies reported in the authors laboratories. NOB-S is the recipient of NHMRC funding (APP1142472, APP1158841, APP1185426), ARC funding (DP210102781, DP160101312, LE200100163), Cancer Council Victoria funding (APP1163284) and Australian Dental Research Funding in antimicrobial materials and research is supported by the Centre for Oral Health Research in the Basic and Clinical Oral Sciences Division at The Melbourne Dental School.