Journal article
Haematological response in experimental human Plasmodium falciparum and Plasmodium vivax malaria
SD Woolley, L Marquart, J Woodford, S Chalon, JJ Moehrle, JS McCarthy, BE Barber
Malaria Journal | BMC | Published : 2021
Abstract
Background: Malaria-associated anaemia, arising from symptomatic, asymptomatic and submicroscopic infections, is a significant cause of morbidity worldwide. Induced blood stage malaria volunteer infection studies (IBSM-VIS) provide a unique opportunity to evaluate the haematological response to early Plasmodium falciparum and Plasmodium vivax infection. Methods: This study was an analysis of the haemoglobin, red cell counts, and parasitaemia data from 315 participants enrolled in IBSM-VIS between 2012 and 2019, including 269 participants inoculated with the 3D7 strain of P. falciparum (Pf3D7), 15 with an artemisinin-resistant P. falciparum strain (PfK13) and 46 with P. vivax. Factors associa..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
QIMR Berghofer Medical Research Institute, Medicines for Malaria Venture, Cadila Healthcare Ltd and Merck Ltd sponsored and funded the studies. JSM received funding from a National Health and Medical Research Council of Australia (NHMRC) program Grant (1132975). JSM is also supported by a NHMRC Practitioner Fellowship.