Journal article
Weight is More Informative than Body Mass Index for Predicting Postmenopausal Breast Cancer Risk: Prospective Family Study Cohort (ProF-SC)
Z Ye, S Li, GS Dite, TL Nguyen, RJ MacInnis, IL Andrulis, SS Buys, MB Daly, EM John, AW Kurian, JM Genkinger, WK Chung, KA Phillips, H Thorne, IM Winship, RL Milne, PA Dugue, MC Southey, GG Giles, M Beth Terry Show all
Cancer Prevention Research | AMER ASSOC CANCER RESEARCH | Published : 2022
Abstract
We considered whether weight is more informative than body mass index (BMI) = weight/height2 when predicting breast cancer risk for postmenopausal women, and if the weight association differs by underlying familial risk. We studied 6,761 women postmenopausal at baseline with a wide range of familial risk from 2,364 families in the Prospective Family Study Cohort. Participants were followed for on average 11.45 years and there were 416 incident breast cancers. We used Cox regression to estimate risk associations with log-transformed weight and BMI after adjusting for underlying familial risk. We compared model fits using the Akaike information criterion (AIC) and nested models using the likel..
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Funding Acknowledgements
We thank Heather Thorne, Eveline Niedermayr, Sharon Guo, Lucy Stanhope, Sarah O'Connor, Sandra Picken, Stephanie Nesci, all the BCFR and kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the many families who contribute to the BCFR and kConFab for their contributions to this resource. The six sites of the BCFR were supported by grant UM1 CA164920 from the NCI; the recipients included E.M. John, I.L. Andrulis, S.S. Buys, M.B. Daly, J.L. Hopper, and M.B. Terry. The Australian BCFR was supported in Australia by the National Health and Medical Research Council, the New South Wales Cancer Council, the Victorian Health Promotion Foundation, the Victorian Breast Cancer Research Consortium, Cancer Australia, and the National Breast Cancer Foundation. J.L. Hopper and M.B. Terry received a grant from the NIH (grant number R01CA159868). kConFab and the kConFab Follow-up Study have received grants from National Breast Cancer Foundation (grant number IF 17), Cancer Australia (grant number 809195), the National Breast Cancer Foundation, and the National Health and Medical Research Council, the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania, and South Australia, and the Cancer Foundation of Western Australia. K.A. Phillips received a grant from the National Health and Medical Research Council (grant number 288704). K.A. Phillips and J.L. Hopper received a grant from the National Health and Medical Research Council (grant numbers 145684). K.A. Phillips, R.L. Milne, and J.L. Hopper received a grant from the National Health and Medical Research Council (grant number 454508), and from Cancer Australia and the National Breast Cancer Foundation (grant number 809195). K.A. Phillips and R.L. Milne received a grant from Cancer Australia and the National Breast Cancer Foundation (grant number 1100868). K.A. Phillips is a National Health and Medical Research Council (Australia) Leadership Fellow (grant number 1195294). Z. Ye is supported by China Scholarship Council-University of Melbourne PhD Scholarship. S. Li is a Victorian Cancer Agency Early Career Research Fellow (ECRF 19020). T.L. Nguyen received a grant from the Cancer Council Victoria (TP900783).