Agreement Between Automated and Manual MRI Volumetry in Alzheimer's Disease: A Systematic Review and Meta-Analysis

Abstract

Background: Automated magnetic resonance imaging (MRI) volumetry is a promising tool to evaluate regional brain volumes in dementia and especially Alzheimer's disease (AD). Purpose: To compare automated methods and the gold standard manual segmentation in measuring regional brain volumes on MRI across healthy controls, patients with mild cognitive impairment, and patients with dementia due to AD. Study Type: Systematic review and meta-analysis. Data Sources: MEDLINE, Embase, and PsycINFO were searched through October 2021. Field Strength: 1.0 T, 1.5 T, or 3.0 T. Assessment: Two review authors independently identified studies for inclusion and extracted data. Methodological quality was assess..