Journal article
Human Papillomavirus Antibody Levels Following Vaccination or Natural Infection among Young Men Who Have Sex with Men
EPF Chow, CK Fairley, H Zou, R Wigan, SM Garland, AM Cornall, S Atchison, SN Tabrizi, MY Chen
Clinical Infectious Diseases | Published : 2022
DOI: 10.1093/cid/ciab1052
Abstract
Background: Australia introduced a school-based gender-neutral human papillomavirus (HPV) vaccination program for girls and boys aged 12-13 years in 2013. We examined HPV type-specific antibody levels in unvaccinated young men who have sex with men (MSM) with natural infection and compared these with levels in those vaccinated against HPV. Methods: Serum specimens at baseline were collected from MSM aged 16-20 years in the HYPER1 (Human Papillomavirus in Young People Epidemiological Research) and HYPER2 studies, conducted in 2010-2013 and 2017-2019, respectively. Merck's 4-plex HPV competitive Luminex Immunoassay was used to quantify HPV6-, HPV11-, HPV16-, and HPV18-specific antibodies. We c..
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Awarded by Merck Co.
Funding Acknowledgements
The HYPER2 study was funded by Merck & Co. (54860); funding was provided to the Melbourne Sexual Health Centre to conduct this investigator-initiated study.