Journal article
Parental preconception BMI trajectories from childhood to adolescence and asthma in the future offspring
G Bowatte, DS Bui, S Priyankara, AJ Lowe, JL Perret, CJ Lodge, GS Hamilton, B Erbas, P Thomas, B Thompson, V Schlünssen, D Martino, JW Holloway, C Svanes, MJ Abramson, EH Walters, SC Dharmage
Journal of Allergy and Clinical Immunology | MOSBY-ELSEVIER | Published : 2022
Abstract
Background: Recent evidence suggests that parental exposures before conception can increase the risk of asthma in offspring. Objective: We investigated the association between parents' preconception body mass index (BMI) trajectories from childhood to adolescence and subsequent risk of asthma in their offspring. Methods: Using group-based trajectory modeling from the Tasmanian Longitudinal Health Study, we identified BMI trajectories for index participants (parents) when aged 4 years to 15 years. Multinomial regression models adjusted for potential confounders were utilized to estimate the association between these early-life parents' BMI trajectories and asthma phenotypes in their subsequen..
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Grants
Awarded by Clifford Craig Foundation
Funding Acknowledgements
Supported by the National Health and Medical Research Council (NHMRC) of Australia (grants 299901 and 1021275); the University of Melbourne, Australia; the Clifford Craig Foundation, Australia; theVictorian, Queensland, and Tasmanian Asthma Foundations, Australia; Royal Hobart Hospital, Australia; the Helen MacPherson Smith Trust, Australia; GlaxoSmithKline, Australia; and John L. Hopper. G.B., J.P., A.L., C.L., and S.C.D. are funded through the NHMRC of Australia. The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.