Bioresponsive Polyphenol-Based Nanoparticles as Thrombolytic Drug Carriers

Haitao Yu; Jason S Palazzolo; Jiajing Zhou; Yingjie Hu; Beeri Niego; Shuaijun Pan; Yi Ju; Ting-Yi Wang; Zhixing Lin; Christoph E Hagemeyer; Frank Caruso

Journal article

Bioresponsive Polyphenol-Based Nanoparticles as Thrombolytic Drug Carriers

Haitao Yu, Jason S Palazzolo, Jiajing Zhou, Yingjie Hu, Beeri Niego, Shuaijun Pan, Yi Ju, Ting-Yi Wang, Zhixing Lin, Christoph E Hagemeyer, Frank Caruso

ACS APPLIED MATERIALS & INTERFACES | AMER CHEMICAL SOC | Published : 2022

DOI: 10.1021/acsami.1c19820

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Abstract

Thrombolytic (clot-busting) therapies with plasminogen activators (PAs) are first-line treatments against acute thrombosis and ischemic stroke. However, limitations such as narrow therapeutic windows, low success rates, and bleeding complications hinder their clinical use. Drug-loaded polyphenol-based nanoparticles (NPs) could address these shortfalls by delivering a more targeted and safer thrombolysis, coupled with advantages such as improved biocompatibility and higher stability in vivo. Herein, a template-mediated polyphenol-based supramolecular assembly strategy is used to prepare nanocarriers of thrombolytic drugs. A thrombin-dependent drug release mechanism is integrated using tannic ..

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University of Melbourne Researchers

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC Senior Principal Research Fellowship

Awarded by NHMRC Research Fellowship

Awarded by Australian Rotary Health, Rotary District

Funding Acknowledgements

We thank Dr. Karen Alt, Anukreity Ale, Dr. Christina Cortez-Jugo, Dr. Yiyuan Han, and Jingqu Chen for helpful discussions and/or support with the characterization studies. This research was funded and supported by a National Health and Medical Research Council (NHMRC) Project Grant (GNT1138361, C.E.H. and F.C.) . F.C. and C.E.H. acknowledge the awarding of an NHMRC Senior Principal Research Fellowship (GNT1135806) and an NHMRC Research Fellowship (GNT1154270) , respectively. J.S.P. acknowledges support from Australian Rotary Health, Rotary District 9830, and the Australian Government Research Training Program (RTP) Scholarship.