The Role of ZntA in Klebsiella pneumoniae Zinc Homeostasis

EA Maunders; K Ganio; AJ Hayes; SL Neville; MR Davies; RA Strugnell; CA McDevitt; A Tan

Journal article

The Role of ZntA in Klebsiella pneumoniae Zinc Homeostasis

EA Maunders, K Ganio, AJ Hayes, SL Neville, MR Davies, RA Strugnell, CA McDevitt, A Tan

Microbiology Spectrum | AMER SOC MICROBIOLOGY | Published : 2022

DOI: 10.1128/spectrum.01773-21

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Abstract

Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that is a leading cause of healthcare-associated infections, including pneumonia, urinary tract infections, and sepsis. Essential to the colonization and infection by K. pneumoniae is the acquisition of nutrients, such as the transition metal ion zinc. Zinc has crucial structural and catalytic roles in the proteome of all organisms. Nevertheless, in excess, it has the potential to mediate significant toxicity by dysregulating the homeostasis of other transition elements, disrupting enzymatic processes, and perturbing metalloprotein cofactor acquisition. Here, we sought to elucidate the zinc detoxification mechanisms of K. pneum..

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University of Melbourne Researchers

Andrew Hayes Author

Stephanie Neville Author

Mark Davies Author

Dick Strugnell Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) grant numbers 1122582 and 1180826 to C.A.M. This work was also supported by the Australian Research Council (ARC) Discovery Project Grant to C.A.M. (DP170102102). S.L.N. is an NHMRC Early Career Research Fellow (1142695) and C.A.M. is an ARC Future Fellow (FT170100006). The content of this study is solely the responsibility of the authors and does not necessarily represent the official views of the funding bodies.