Journal article
Towards guided and automated programming of subthalamic area stimulation in Parkinson's disease
SS Xu, NC Sinclair, KJ Bulluss, T Perera, WL Lee, HJ Mcdermott, W Thevathasan
Brain Communications | Published : 2022
Abstract
Selecting the ideal contact to apply subthalamic nucleus deep brain stimulation in Parkinson's disease can be an arduous process, with outcomes highly dependent on clinician expertise. This study aims to assess whether neuronal signals recorded intraoperatively in awake patients, and the anatomical location of contacts, can assist programming. In a cohort of 14 patients with Parkinson's disease, implanted with subthalamic nucleus deep brain stimulation, the four contacts on each lead in the 28 hemispheres were ranked according to proximity to a nominated ideal anatomical location and power of the following neuronal signals: evoked resonant neural activity, beta oscillations and high-frequenc..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The work was funded by the National Health and Medical Research Council [development grant #1177815, project grant #1103238, post-graduate scholarship #1133295 (S.S. X.)], Colonial Foundation, St Vincent's Hospital Research Endowment Fund and Lions International. The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program.