Journal article
Trend in Sensitivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serology One Year after Mild and Asymptomatic Coronavirus Disease 2019 (COVID-19): Unpacking Potential Bias in Seroprevalence Studies
CR Bailie, YY Tseng, L Carolan, MD Kirk, S Nicholson, A Fox, SG Sullivan
Clinical Infectious Diseases | Published : 2022
DOI: 10.1093/cid/ciac020
Abstract
A key aim of serosurveillance during the coronavirus disease 2019 (COVID-19) pandemic has been to estimate the prevalence of prior infection, by correcting crude seroprevalence against estimated test performance for polymerase chain reaction (PCR)-confirmed COVID-19. We show that poor generalizability of sensitivity estimates to some target populations may lead to substantial underestimation of case numbers.
Grants
Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
Y.-Y. T. is supported by the National Institutes of Health (NIH) (grant number R01AI141534).The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health. Recruitment of this cohort was partially supported by the former Victorian Department of Health and Human Services.