Journal article
Early life environmental factors associated with autism spectrum disorder symptoms in children at age 2 years: A birth cohort study
C Pham, C Symeonides, M O’Hely, PD Sly, LD Knibbs, S Thomson, P Vuillermin, R Saffery, AL Ponsonby
Autism | Published : 2022
Abstract
Mounting evidence finds that early life environmental factors increased the probability of autism spectrum disorder. We estimated prospective associations between early life environmental factors and autism spectrum disorder symptoms in children at the age of 2 years in a population-derived birth cohort, the Barwon Infant Study. Autism spectrum disorder symptoms at the age of 2 years strongly predicted autism spectrum disorder diagnosis by the age of 4 years (area under curve = 0.93; 95% CI (0.82, 1.00)). After adjusting for child’s sex and age at the time of behavioural assessment, markers of socioeconomic disadvantage, such as lower household income and lone parental status; maternal healt..
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Awarded by Jack Brockhoff Foundation
Funding Acknowledgements
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The establishment work and infrastructure for the Barwon Infant Study (BIS) was provided by the Murdoch Children's Research Institute, Deakin University and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council (NHMRC) of Australia, the Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fundraising Committee Barwon Health, the Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited and the Percy Baxter Charitable Trust and Perpetual Trustees. In-kind support was provided by the Cotton On Foundation and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. C.P. is supported by a Melbourne Children's LifeCourse PhD Support Program scholarship and funded by Royal Children's Hospital Foundation grant (#2018-984). C.S. is supported by the NHMRC PhD scholarship. This work was also supported by NHMRC Senior Research Fellowships (APP1008396 to A.-L. P.; APP1045161 to R.S.).