Baseline data of a sequential multiple assignment randomized trial (STEP study)

JA Hartmann; B Nelson; GP Amminger; J Spark; HP Yuen; MJ Kerr; A Polari; N Wallis; J Blasioli; L Dixon; C Carter; R Loewy; TA Niendam; M Shumway; PD McGorry

Journal article

Baseline data of a sequential multiple assignment randomized trial (STEP study)

JA Hartmann, B Nelson, GP Amminger, J Spark, HP Yuen, MJ Kerr, A Polari, N Wallis, J Blasioli, L Dixon, C Carter, R Loewy, TA Niendam, M Shumway, PD McGorry

Early Intervention in Psychiatry | Published : 2022

DOI: 10.1111/eip.13263

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Abstract

Aim: Research has shown that preventative intervention in individuals at ultra-high risk of psychosis (UHR) improves symptomatic and functional outcomes. The staged treatment in early psychosis (STEP) trial aims to determine the most effective type, timing and sequence of interventions in the UHR population by sequentially studying the effectiveness of (1) support and problem solving, (2) cognitive-behavioural case management and (3) antidepressant medication with an embedded fast-fail option of (4) omega-3 fatty acids or low-dose antipsychotic medication. This paper presents the recruitment flow and baseline clinical characteristics of the sample. Methods: STEP is a sequential multiple assi..

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