Journal article
PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic b-Cells in Autoimmune Diabetes
B Elvira, V Vandenbempt, J Bauza-Martinez, R Crutzen, J Negueruela, H Ibrahim, ML Winder, MK Brahma, B Vekeriotaite, PJ Martens, SP Singh, F Rossello, P Lybaert, T Otonkoski, C Gysemans, W Wu, EN Gurzov
Diabetes | Published : 2022
DOI: 10.2337/DB21-0443
Abstract
Type 1 diabetes (T1D) results from autoimmune destruction of b-cells in the pancreas. Protein tyrosine phosphatases (PTPs) are candidate genes for T1D and play a key role in autoimmune disease development and b-cell dysfunction. Here, we assessed the global protein and individual PTP profiles in the pancreas from nonob-ese mice with early-onset diabetes (NOD) mice treated with an anti-CD3 monoclonal antibody and interleukin-1 receptor antagonist. The treatment reversed hypergly-cemia, and we observed enhanced expression of PTPN2, a PTP family member and T1D candidate gene, and endoplasmic reticulum (ER) chaperones in the pancreatic islets. To address the functional role of PTPN2 in b-cells, ..
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Awarded by European Research Council
Funding Acknowledgements
This work was supported by a Fonds National de la Recherche Scientifique (FNRS)-MIS grant (33650793), European Research Council Consolidator grant METAPTPs (GA817940), and a JDRF Career Development Award (CDA2019-758-A-N). B.E. and V.V. are supported by an FNRS CR postdoctoral fellowship (34769436) and PhD Aspirant scholarship, respectively. S.P.S. is supported by mandat d'impulsion scientifique -mobilit~e Ulysse (MISU) funding from the FNRS (34772792 [SCHISM]). E.N.G. is a Research Associate of the FNRS (Brussels, Belgium).