Journal article
Does tranexamic acid affect intraventricular hemorrhage growth in acute ICH? An analysis of the STOP-AUST trial
V Yogendrakumar, TY Wu, L Churilov, T Tatlisumak, D Strbian, JS Jeng, TJ Kleinig, G Sharma, BCV Campbell, H Zhao, CY Hsu, A Meretoja, GA Donnan, SM Davis, N Yassi
European Stroke Journal | Published : 2022
Abstract
Background: Trials of tranexamic acid (TXA) in acute intracerebral hemorrhage (ICH) have focused on the imaging outcomes of intraparenchymal hematoma growth. However, intraventricular hemorrhage (IVH) growth is also strongly associated with outcome after ICH. Revised definitions of hematoma expansion incorporating IVH growth have been proposed. Aims: We sought to evaluate the effect of TXA on IVH growth. Methods: We analyzed data from the STOP-AUST trial, a prospective randomized trial comparing TXA to placebo in ICH patients presenting ≤ 4.5 h from symptom onset with a CT-angiography spot sign. New IVH development at follow-up, any interval IVH growth, and IVH growth ≥ 1 mL were compared be..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: STOP-AUST was funded by the Australian National Health and Medical Research Council, (grant: 1081718), and the Royal Melbourne Hospital Foundation.