Journal article
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging
O Leiter, Z Zhuo, R Rust, JM Wasielewska, L Grönnert, S Kowal, RW Overall, VS Adusumilli, DG Blackmore, A Southon, K Ganio, CA McDevitt, N Rund, D Brici, IA Mudiyan, AM Sykes, AE Rünker, S Zocher, S Ayton, AI Bush Show all
Cell Metabolism | CELL PRESS | Published : 2022
Abstract
Although the neurogenesis-enhancing effects of exercise have been extensively studied, the molecular mechanisms underlying this response remain unclear. Here, we propose that this is mediated by the exercise-induced systemic release of the antioxidant selenium transport protein, selenoprotein P (SEPP1). Using knockout mouse models, we confirmed that SEPP1 and its receptor low-density lipoprotein receptor-related protein 8 (LRP8) are required for the exercise-induced increase in adult hippocampal neurogenesis. In vivo selenium infusion increased hippocampal neural precursor cell (NPC) proliferation and adult neurogenesis. Mimicking the effect of exercise through dietary selenium supplementati..
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Awarded by Deutsche Forschungsgemeinschaft
Funding Acknowledgements
This work was funded by the Brazil Family Foundation for Neurology, Australia; the Deutsche Forschungsgemeinschaft SFB 655; and the Clem Jones Centre for Ageing Dementia Research. We thank Anne Karasinsky and Sandra Gunther for care and maintenance of animals and Rowan Tweedale for her helpful comments on the manuscript. Z.Z. was supported by a SUSTech-UQ Joint Graduate Student Scholarship. S.-T.H. was supported by grants from the National Natural Science Foundation of China (81871026) and the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions (2019SHIBS0002 and 2021SHIBS0002).