Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

M Marcucci; TW Painter; D Conen; K Leslie; VV Lomivorotov; D Sessler; MTV Chan; FK Borges; MJ Martínez Zapata; CY Wang; D Xavier; SN Ofori; G Landoni; S Efremov; YV Kleinlugtenbelt; W Szczeklik; D Schmartz; AX Garg; TG Short; M Wittmann; CS Meyhoff; M Amir; D Torres; A Patel; E Duceppe; K Ruetzler; JL Parlow; V Tandon; MK Wang; E Fleischmann; CA Polanczyk; R Jayaram; SV Astrakov; M Rao; T VanHelder; WKK Wu; CC Cheong; S Ayad; M Abubakirov; M Kirov; K Bhatt; M de Nadal; V Likhvantsev; PP Iglesisas; HJ Aguado; M McGillion; A Lamy; RP Whitlock; P Roshanov; D Stillo; I Copland; J Vincent; K Balasubramanian; SI Bangdiwala; B Biccard; A Kurz; S Srinathan; S Petit; J Eikelboom; T Richards; PL Gross; P Alfonsi; G Guyatt; E Belley-Cote; J Spence; W McIntyre; S Yusuf; PJ Devereaux

Journal article

Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

M Marcucci, TW Painter, D Conen, K Leslie, VV Lomivorotov, D Sessler, MTV Chan, FK Borges, MJ Martínez Zapata, CY Wang, D Xavier, SN Ofori, G Landoni, S Efremov, YV Kleinlugtenbelt, W Szczeklik, D Schmartz, AX Garg, TG Short, M Wittmann Show all

Trials | BMC | Published : 2022

DOI: 10.1186/s13063-021-05992-1

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Abstract

Background: For patients undergoing noncardiac surgery, bleeding and hypotension are frequent and associated with increased mortality and cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent with the potential to reduce surgical bleeding; however, there is uncertainty about its efficacy and safety in noncardiac surgery. Although usual perioperative care is commonly consistent with a hypertension-avoidance strategy (i.e., most patients continue their antihypertensive medications throughout the perioperative period and intraoperative mean arterial pressures of 60 mmHg are commonly accepted), a hypotension-avoidance strategy may improve perioperative outcomes. Method..

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University of Melbourne Researchers

Kate Leslie Author

Related Projects (1)

TRANEXAMIC ACID AND HYPOTENSION-AVOIDANCE TO PREVENT DEATH AND MAJOR COMPLICATIONS AFTER NONCARDIAC SURGERY (PERIOPERATIVE ISCHEMIC EVALUATION-3 – THE POISE-3 TRIAL)

Bleeding and low blood pressure are common and dangerous complications of anaesthesia and surgery. We propose a large international study to..

Grants

Awarded by Boehringer Ingelheim

Funding Acknowledgements

The study is supported by the following grants: Canadian Institutes of Health Research (CIHR) Foundation Grant awarded to PJD (FDN-143302), Canada; General Research Fund 14104419, Research Grant Council, Hong Kong SAR, China; and National Health and Medical Research Council, Funding Schemes, NHMRC Project Grant 1162362, Australia. MM holds a McMaster University Department of Medicine Career Research Award and a Physicians' Services Incorporated (PSI) Foundation Mid-Career Clinical Research Award to support her research work in perioperative medicine. FKB holds a McMaster University Department of Medicine Career Research Award to support her research work in perioperative medicine.