Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction.

Ciara N Murphy; Catherine A Cluver; Susan P Walker; Emerson Keenan; Roxanne Hastie; Teresa M MacDonald; Natalie J Hannan; Fiona C Brownfoot; Ping Cannon; Stephen Tong; Tu'uhevaha J Kaitu'u-Lino

Journal article

Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction.

Ciara N Murphy, Catherine A Cluver, Susan P Walker, Emerson Keenan, Roxanne Hastie, Teresa M MacDonald, Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal of Clinical Medicine | MDPI AG | Published : 2022

DOI: 10.3390/jcm11040901

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Abstract

Fetal growth restriction (FGR), when undetected antenatally, is the biggest risk factor for preventable stillbirth. Maternal circulating SPINT1 is reduced in pregnancies, which ultimately deliver small for gestational age (SGA) infants at term (birthweight < 10th centile), compared to appropriate for gestational age (AGA) infants (birthweight ≥ 10th centile). SPINT1 is also reduced in FGR diagnosed before 34 weeks' gestation. We hypothesised that circulating SPINT1 would be decreased in co-existing preterm preeclampsia and FGR. Plasma SPINT1 was measured in samples obtained from two double-blind, randomised therapeutic trials. In the Preeclampsia Intervention with Esomeprazole trial, circula..

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University of Melbourne Researchers

Susan Walker Author

Emerson Keenan Author

Roxanne Hastie Author

Teresa MacDonald Author

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

Funding for this work was provided by the National Health and Medical Research Council (#1065854, #116071, #20000732) as well as National Health and Medical Research Council Fellowships to T.K.L. (#1159261), N.J.H. (#1146128), S.T. (#1136418), and R.H. (#1176922). The funders played no role in study design or analysis.