Journal article
Cardiovascular Risk Associated with Poorer Memory in Middle-Aged Adults from the Healthy Brain Project
N Yassi, MP Pase, RF Buckley, E Rosenich, R Watson, P Maruff, YY Lim
Journal of Alzheimer S Disease | IOS PRESS | Published : 2022
DOI: 10.3233/JAD-215375
Abstract
Background: Midlife cardiovascular risk factors (CVRF) are associated with reduced cognition and an increased risk of dementia. Objective: To further investigate this association using remote unsupervised online assessment of cognition and cardiovascular risk in middle-aged adults; and to explore the extent to which the association is altered by carriage of the APOE ϵ4 allele. Methods: The Healthy Brain Project is an online cohort of middle-aged cognitively unimpaired adults (40-70 years) who have undergone cognitive assessment and provided self-reports of demographic and health history. Cardiovascular risk was determined by ascertaining history of hypertension, hypercholesterolemia, diabete..
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Awarded by National Institutes of Health
Funding Acknowledgements
The Healthy Brain Project (healthybrainproject. org.au) is funded by the National Health and Medical Research Council (GNT1158384, GNT1147465, GNT1111603, GNT1105576, GNT1104273, GNT 1158384, GNT1171816), the Alzheimer's Association (AARG-17-591424, AARG-18-591358, AA RG-19-643133), the Dementia Australia Research Foundation, the Bethlehem Griffiths Research Foundation, the Yulgilbar Alzheimer's Research Program, the National Heart Foundation of Australia (102052), and the Charleston Conference for Alzheimer's Disease. We thank our study partners (PearlArc, SRC Innovations, Cogstate Ltd and Cambridge Cognition) for their ongoing support. YY Lim is supported by an NHMRC Career Development Fellowship (GNT1162645). MP Pase is supported by a Heart Foundation Future Leader Fellowship (GNT102052). RF Buckley is supported by a National Institutes of Health K99-R00 award (K99AG061238).