Spatiotemporal Adaptations of Macrophage and Dendritic Cell Development and Function

A Roquilly; JD Mintern; JA Villadangos

Journal article

Spatiotemporal Adaptations of Macrophage and Dendritic Cell Development and Function

A Roquilly, JD Mintern, JA Villadangos

Annual Review of Immunology | ANNUAL REVIEWS | Published : 2022

DOI: 10.1146/annurev-immunol-101320-031931

Abstract

Macrophages and conventional dendritic cells (cDCs) are distributed throughout the body, maintaining tissue homeostasis and tolerance to self and orchestrating innate and adaptive immunity against infection and cancer. As they complement each other, it is important to understand how they cooperate and the mechanisms that integrate their functions. Both are exposed to commensal microbes, pathogens, and other environmental challenges that differ widely among anatomical locations and over time. To adjust to these varying conditions, macrophages and cDCs acquire spatiotemporal adaptations (STAs) at different stages of their life cycle that determine how they respond to infection. The STAs acquir..

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University of Melbourne Researchers

Antoine Roquilly Author

Justine Mintern Author

Jose Villadangos Author

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Grants

Awarded by Horizon 2020 Framework Programme

Funding Acknowledgements

A.R. is supported by the European Union's Horizon 2020 research and innovation program under grant agreement number 847782 and the Agence National de la Recherche (ANR) PROGRAM project. J.A.V. is supported by a Principal Research Fellowship (1154502), a program grant (1113293), and a project grant (1163090) of the National Health and Medical Research Council of Australia. J.D.M. is supported by an Australian Research Council Future Fellowship (FT180100521), an Australian Research Council Discovery Project (DP190101242), and a National Health and Medical Research Council of Australia Ideas Grant (2000683).