Journal article
Case Report: Cytomegalovirus Disease Is an Under-Recognized Contributor to Morbidity and Mortality in Common Variable Immunodeficiency
S Chan, J Godsell, M Horton, A Farchione, LJ Howson, M Margetts, C Jin, J Chatelier, M Yong, J Sasadeusz, JA Douglass, CA Slade, VL Bryant
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2022
Open access
Abstract
Background: Common Variable Immunodeficiency (CVID) is classified as a ‘Predominantly Antibody Deficiency’ (PAD), but there is emerging evidence of cellular immunodeficiency in a subset of patients. This evidence includes CVID patients diagnosed with cytomegalovirus (CMV) infection, a hallmark of ‘combined immunodeficiency’. CMV infection also has the potential to drive immune dysregulation contributing to significant morbidity and mortality in CVID. We aim to determine the extent of cellular immune dysfunction in CVID patients, and whether this correlates with CMV infection status. Methods: We conducted a single-center retrospective cohort study of individuals with CVID at the Royal Melbour..
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
The authors acknowledge the Melbourne Genomics Health Alliance, supported by the Victorian Government and Alliance members, and the Australian National Health and Medical Research Council (NHMRC, Project Grant 1127198 for VB). SC receives support through a WEHI Scientific Excellence PhD Scholarship. VB and CS are supported by Sir Clive McPherson Family Research Fellowships. VB is also supported by the Royal Melbourne Hospital DW Keir Fellowship, the Victorian State Government Operational Infrastructure Scheme and Australian Government NHMRC IRIISS, the Pam and Harold Holmes Foundation, and a WEHI Innovation Grant. CS also receives support from the Scobie and Claire Mackinnon Trust. The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.